Cotinine(COT) Rapid Test Kit (Urine) Description

Cotinine(COT) Rapid Test Kit (Urine) Description

Release date： 2026-01-27 15:39:43 Readings： 2 Author： admin

Cotinine(COT) Rapid Test Kit is an immunoassay intended for the qualitative detection of Cotinine(COT) in human urine at a cut-off concentration of 50/100/200/300/500 ng/ml.

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Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produces stimulation of the autonomic ganglia and central nervous system when in humans. Nicotine is a drug to which virtually every member of a tobacco-smoking society is exposed whether through direct contact or second-hand inhalation. In addition to tobacco, nicotine is also commercially available as the active ingredient in smoking replacement therapies such as nicotine gum, transdermal patches and nasal sprays.

In a 24-hour urine, approximately 5% of a nicotine dose is excreted as unchanged drug with 10% as cotinine and 35% as hydroxycotinine; the concentrations of other metabolites are believed to account for less than 5%. While cotinine is thought to be an inactive metabolite, it’s elimination profile is more stable than that of nicotine which is largely urine pH dependent. As a result, cotinine is considered a good biological marker for determining nicotine use. The plasma half-life of nicotine is approximately 60 minutes following inhalation or parenteral administration. Nicotine and cotinine are rapidly eliminated by the kidney; the window of detection for cotinine in urine at a cutoff level of 200 ng/mL is expected to be up to 2-3 days after nicotine use.

Jinan Chuangxingwell Biotech Co., Ltd.

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