Ferritin is a universal intracellular protein that stores iron and releases it in a controlled
ashion. The protein is produced by almost all living organisms. In humans, It acts as a
uffer against iron deficiency and iron overload. Ferritin is found in most tissues as a
ytosolic protein, but small amounts are secreted into the serum where it functions as an
ron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in
he body, hence serum ferritin is used as a diagnostic test for iron-deficiency anemia.
ecent study suggests that ferritin provides a more sensitive, specific and reliable
easurement for determining iron deficiency at an early stage. On the other hand, patients
ith ferritin levels that are higher than the reference range may be indicative of conditions
uch as iron overload, infections, inflammations, collagen diseases, hepatic diseases,
eoplastic diseases and chronic renal failure.
ormal Reference Value: Female: 12.0-150.0ng/mL; Male: 15.0-200.0ng/mL.
ote: Individual reference range is suggested to be established for each laboratory.
The Ferritin Rapid Quantitative Test is based on fluorescence immunoassay
echnology. The Aehealth Ferritin Rapid Quantitative test uses a sandwich
mmunodetection method, when sample is added to the sample well of the test Cassette,
he fluorescence-labeled detector Ferritin antibody binds to Ferritin antigen in blood
pecimen. As the sample mixture migrates on the nitrocellulose matrix of test strip by
apillary action, the complexes of detector antibody and Ferritin are captured to Ferritin
ntibody that has been immobilized on test strip. Thus the more Ferritin antigen is in blood
pecimen, the more complexes are accumulated on test strip. Signal intensity of
luorescence of detector antibody reflects amount of Ferritin captured and Aehealth FIA
eter shows Ferritin concentrations in blood specimen.
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